Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response | Zendy

Evan A. Thackaberry | Zendy; Cindy Farman | Zendy; Fiona Zhong | Zendy; Florence Lorget | Zendy; Karin Staflin | Zendy; Angelique Cercillieux | Zendy; Paul E. Miller | Zendy; Chris Schuetz | Zendy; Debby P. Chang | Zendy; Amin Famili | Zendy; Ann L. Daugherty | Zendy; Karthikan Rajagopal | Zendy; Vladimir Bantseev | Zendy

Open Access

Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response

Author(s) -

Evan A. Thackaberry,

Cindy Farman,

Fiona Zhong,

Florence Lorget,

Karin Staflin,

Angelique Cercillieux,

Paul E. Miller,

Chris Schuetz,

Debby P. Chang,

Amin Famili,

Ann L. Daugherty,

Karthikan Rajagopal,

Vladimir Bantseev

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-21334

Subject(s) - plga , toxicity , pharmacology , proinflammatory cytokine , cytokine , immune system , peripheral blood mononuclear cell , medicine , in vitro , inflammation , chemistry , immunology , biochemistry

Poly(lactic-co-glycolic) acid (PLGA) inserts have been successfully developed for the treatment of posterior eye disease as a means of reducing injection frequency of intravitreally administered therapeutics. PLGA microspheres are also of interest for the delivery of intravitreal drugs, since they offer the advantage of being easily injected without surgical procedures or large injectors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research