Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain | Zendy

Daniel A. Culver | Zendy; Albert Dahan | Zendy; Daiva Bajorunas | Zendy; Maria Jeziorska | Zendy; Monique van Velzen | Zendy; Leon Aarts | Zendy; Jinny Tavee | Zendy; Martijn R. Tannemaat | Zendy; Ann Dunne | Zendy; Rita I. Kirk | Zendy; Ioannis N. Petropoulos | Zendy; Anthony Cerami | Zendy; Rayaz A. Malik | Zendy; Michael Brines | Zendy

Open Access

Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain

Author(s) -

Daniel A. Culver,

Albert Dahan,

Daiva Bajorunas,

Maria Jeziorska,

Monique van Velzen,

Leon Aarts,

Jinny Tavee,

Martijn R. Tannemaat,

Ann Dunne,

Rita I. Kirk,

Ioannis N. Petropoulos,

Anthony Cerami,

Rayaz A. Malik,

Michael Brines

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-21291

Subject(s) - medicine , placebo , nerve fiber , neuropathic pain , clinical endpoint , surrogate endpoint , randomized controlled trial , anesthesia , pathology , anatomy , alternative medicine

Sarcoidosis frequently is complicated by small nerve fiber loss (SNFL), which can be quantified using corneal confocal microscopy (CCM). Prior studies suggest that the innate repair receptor agonist cibinetide reverses corneal nerve loss. This phase 2b, 28-day, randomized trial of 64 subjects with sarcoid-associated SNFL and neuropathic pain assessed the effect of cibinetide on corneal nerve fiber area (CNFA) and regenerating intraepidermal fibers (GAP-43+) as surrogate endpoints for disease modification, pain severity, and functional capacity (6-minute walk test [6MWT]).

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