Open AccessCRISPR/Cas9–Mediated Mutation of αA-Crystallin Gene Induces Congenital Cataracts in Rabbits
Author(s) -
Lin Yuan,
Haobin Yao,
Yuxin Xu,
Mao Chen,
Jichao Deng,
Yuning Song,
Tingting Sui,
Yong Wang,
Yongye Huang,
Zhanjun Li,
Liangxue Lai
Publication year - 2017
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.16-21287
Subject(s) - crystallin , biology , microphthalmia , cataracts , microbiology and biotechnology , gene knockout , genetics , gene
The present study aimed to investigate the role of the αA-crystallin gene in inducing congenital cataracts in rabbits and to construct a novel animal model for characterization and pathologic analysis of congenital cataracts for future research.
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