Open AccessGene Expression and Pathways Underlying Form Deprivation Myopia in the Guinea Pig Sclera
Author(s) -
Nethrajeith Srinivasalu,
Sally A. McFadden,
Callan Medcalf,
Lena Fuchs,
Jessica Chung,
Gayle K. Philip,
Andrea J. Richardson,
Moeen Riaz,
Paul N. Baird
Publication year - 2018
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.16-21278
Subject(s) - sclera , gene expression , gene , biology , microbiology and biotechnology , genetics
Posterior scleral remodeling accompanies myopia. In guinea pigs developing myopia, the region around the optic nerve (peripapillary zone, PPZ) rapidly expands followed by inhibition in eye size in the periphery. We studied the differential gene expression in the sclera that accompanies these changes.
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