Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development | Zendy

Seungwoon Seo | Zendy; Sam LiSheng Chen | Zendy; Wenzhong Liu | Zendy; Demin Zhao | Zendy; Kathryn M. Schultz | Zendy; Amy Sasman | Zendy; Ting Liu | Zendy; Hao F. Zhang | Zendy; Philip J. Gage | Zendy; Tsutomu Kume | Zendy

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Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development

Author(s) -

Seungwoon Seo,

Sam LiSheng Chen,

Wenzhong Liu,

Demin Zhao,

Kathryn M. Schultz,

Amy Sasman,

Ting Liu,

Hao F. Zhang,

Philip J. Gage,

Tsutomu Kume

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-21217

Subject(s) - neural crest , wnt signaling pathway , ectopic expression , biology , cornea , microbiology and biotechnology , genetics , signal transduction , gene , neuroscience , embryo

The large Forkhead (Fox) transcription factor family has essential roles in development, and mutations cause a wide range of ocular and nonocular disease. One member, Foxc2 is expressed in neural crest (NC)-derived periocular mesenchymal cells of the developing murine eye; however, its precise role in the development, establishment, and maintenance of the ocular surface has yet to be investigated.

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