Loss of Melanopsin-Expressing Retinal Ganglion Cells in Patients With Diabetic Retinopathy | Zendy

Elisabeth Anne Adanma Obara | Zendy; Jens Hannibal | Zendy; Steffen Heegaard | Zendy; Jan Fahrenkrug | Zendy

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Loss of Melanopsin-Expressing Retinal Ganglion Cells in Patients With Diabetic Retinopathy

Author(s) -

Elisabeth Anne Adanma Obara,

Jens Hannibal,

Steffen Heegaard,

Jan Fahrenkrug

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-21168

Subject(s) - melanopsin , retina , inner nuclear layer , circadian rhythm , diabetic retinopathy , endocrinology , ganglion cell layer , retinal , biology , medicine , intrinsically photosensitive retinal ganglion cells , ganglion , ophthalmology , retinal ganglion cell , anatomy , neuroscience , diabetes mellitus , photopigment

Photo-entrainment of the circadian clock is mediated by melanopsin-expressing retinal ganglion cells (mRGCs) located in the retina. Patients suffering from diabetic retinopathy (DR) show impairment of light regulated circadian activity such as sleep disorders, altered blood pressure, and abnormal melatonin secretion. The aim of this study was to assess the impact of DR on the expression of mRGCs in the human retina.

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