Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1delTTAG/+ Mice | Zendy

Juan Manuel Chao de la Barca | Zendy; Gilles Simard | Zendy; Emmanuelle Sarzi | Zendy; Tanguy Chaumette | Zendy; Guillaume Rousseau | Zendy; Stéphanie Chupin | Zendy; Cédric Gadras | Zendy; Lydie Tessier | Zendy; Marc Ferré | Zendy; Arnaud Chevrollier | Zendy; Valérie DesquiretDumas | Zendy; Naïg Guéguen | Zendy; Stéphanie Leruez | Zendy; Christophe Verny | Zendy; Dan Miléa | Zendy; Dominique Bonneau | Zendy; Patrizia AmatiBonneau | Zendy; Vincent Procaccio | Zendy; Christian Hamel | Zendy; Guy Lenaers | Zendy; Pascal Reynier | Zendy; Delphine PrunierMirebeau | Zendy

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Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1^delTTAG/+ Mice

Author(s) -

Juan Manuel Chao de la Barca,

Gilles Simard,

Emmanuelle Sarzi,

Tanguy Chaumette,

Guillaume Rousseau,

Stéphanie Chupin,

Cédric Gadras,

Lydie Tessier,

Marc Ferré,

Arnaud Chevrollier,

Valérie DesquiretDumas,

Naïg Guéguen,

Stéphanie Leruez,

Christophe Verny,

Dan Miléa,

Dominique Bonneau,

Patrizia AmatiBonneau,

Vincent Procaccio,

Christian Hamel,

Guy Lenaers,

Pascal Reynier,

Delphine PrunierMirebeau

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-21116

Subject(s) - optic nerve , carnosine , atrophy , medicine , endocrinology , optic neuropathy , biology , retina , retinal ganglion cell , pathology , chemistry , anatomy , neuroscience

Dominant optic atrophy (MIM No. 165500) is a blinding condition related to mutations in OPA1, a gene encoding a large GTPase involved in mitochondrial inner membrane dynamics. Although several mouse models mimicking the disease have been developed, the pathophysiological mechanisms responsible for retinal ganglion cell degeneration remain poorly understood.

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