T Cell–Derived Granulocyte-Macrophage Colony-Stimulating Factor Contributes to Dry Eye Disease Pathogenesis by Promoting CD11b+ Myeloid Cell Maturation and Migration | Zendy

Thomas H. Dohlman | Zendy; Julia Ding | Zendy; Reza Dana | Zendy; Sunil K. Chauhan | Zendy

Open Access

T Cell–Derived Granulocyte-Macrophage Colony-Stimulating Factor Contributes to Dry Eye Disease Pathogenesis by Promoting CD11b+ Myeloid Cell Maturation and Migration

Author(s) -

Thomas H. Dohlman,

Julia Ding,

Reza Dana,

Sunil K. Chauhan

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20789

Subject(s) - immunology , granulocyte macrophage colony stimulating factor , integrin alpha m , pathogenesis , macrophage , myeloid , t cell , antibody , flow cytometry , cell , medicine , cytokine , biology , in vitro , immune system , biochemistry , genetics

Growing evidence suggests that granulocyte-macrophage colony-stimulating factor (GM-CSF) contributes to T helper 17 (Th17) cell-associated immunoinflammatory diseases. The purpose of this study was to evaluate the effect of T cell-derived GM-CSF on CD11b+ myeloid cell function in dry eye disease (DED).

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