Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome | Zendy

Isobel Massie | Zendy; Kristina Spaniol | Zendy; Andreas Barbian | Zendy; Gereon Poschmann | Zendy; Kai Stühler | Zendy; Gerd Geerling | Zendy; Marco Metzger | Zendy; Sonja Mertsch | Zendy; Stefan Schrader | Zendy

Open Access

Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome

Author(s) -

Isobel Massie,

Kristina Spaniol,

Andreas Barbian,

Gereon Poschmann,

Kai Stühler,

Gerd Geerling,

Marco Metzger,

Sonja Mertsch,

Stefan Schrader

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20759

Subject(s) - decellularization , jejunum , lacrimal gland , in vitro , dry eyes , matrix (chemical analysis) , ophthalmology , anatomy , medicine , biology , extracellular matrix , chemistry , pathology , microbiology and biotechnology , chromatography , biochemistry

Dry eye syndrome (DES) can cause blindness in severe cases, but mainly palliative treatments exist. A tissue-engineered lacrimal gland (LG) could provide a curative treatment. We aimed to evaluate decellularized porcine jejunum (SIS-Muc) as a scaffold for porcine LG epithelial cells.

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