Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy | Zendy

Sandra Petrus-Reurer | Zendy; Hammurabi Bartuma | Zendy; Monica Aronsson | Zendy; Sofie Westman | Zendy; Fredrik Lanner | Zendy; Helder André | Zendy; Anders Kvanta | Zendy

Open Access

Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy

Author(s) -

Sandra Petrus-Reurer,

Hammurabi Bartuma,

Monica Aronsson,

Sofie Westman,

Fredrik Lanner,

Helder André,

Anders Kvanta

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20738

Subject(s) - retinal pigment epithelium , embryonic stem cell , retinal degeneration , bleb (medicine) , atrophy , pars plana , retinal , macular degeneration , pathology , stem cell , retina , transplantation , anatomy , ophthalmology , medicine , biology , microbiology and biotechnology , vitrectomy , surgery , neuroscience , intraocular pressure , visual acuity , biochemistry , trabeculectomy , gene

Subretinal suspension transplants of human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) have the capacity to form functional monolayers in naive eyes. We explore hESC-RPE integration when transplanted in suspension to a large-eyed model of geographic atrophy (GA).

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