Aberrant Buildup of All-Trans-Retinal Dimer, a Nonpyridinium Bisretinoid Lipofuscin Fluorophore, Contributes to the Degeneration of the Retinal Pigment Epithelium | Zendy

Junli Zhao | Zendy; Yi Liao | Zendy; Jingmeng Chen | Zendy; Xinran Dong | Zendy; Zhan Gao | Zendy; Houjian Zhang | Zendy; Xiaodan Wu | Zendy; Zuguo Liu | Zendy; Yalin Wu | Zendy

Open Access

Aberrant Buildup of All-Trans-Retinal Dimer, a Nonpyridinium Bisretinoid Lipofuscin Fluorophore, Contributes to the Degeneration of the Retinal Pigment Epithelium

Author(s) -

Junli Zhao,

Yi Liao,

Jingmeng Chen,

Xinran Dong,

Zhan Gao,

Houjian Zhang,

Xiaodan Wu,

Zuguo Liu,

Yalin Wu

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20734

Subject(s) - microbiology and biotechnology , lipofuscin , apoptosis , retinal degeneration , retinal pigment epithelium , biology , cell cycle , dna damage , visual phototransduction , retinal , programmed cell death , chemistry , biochemistry , dna

Nondegradable fluorophores that accumulate as deleterious lipofuscin of RPE are involved in pathological mechanisms leading to the degeneration of RPE in AMD. A2E, a major component of RPE lipofuscin, could cause damage to RPE cells. Nevertheless, all-trans-retinal dimer (atRAL dimer) was found to be much more abundant than that of A2E in eyes of Abca4-/-Rdh8-/- double-knockout (DKO) mice, a rodent model showing the typical characteristics of retinopathies in AMD patients. Our aim was to elucidate the effect and mechanism of atRAL dimer-induced RPE degeneration.

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