Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma | Zendy

Wei Zhu | Zendy; Ankur Jain | Zendy; Oliver W. Gramlich | Zendy; Budd A. Tucker | Zendy; Val C. Sheffield | Zendy; Markus H. Kuehn | Zendy

Open Access

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

Author(s) -

Wei Zhu,

Ankur Jain,

Oliver W. Gramlich,

Budd A. Tucker,

Val C. Sheffield,

Markus H. Kuehn

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20672

Subject(s) - trabecular meshwork , myocilin , transplantation , induced pluripotent stem cell , glaucoma , endoplasmic reticulum , ophthalmology , medicine , genetically modified mouse , unfolded protein response , andrology , transgene , chemistry , microbiology and biotechnology , biology , embryonic stem cell , biochemistry , gene

Primary open-angle glaucoma (POAG) is particularly common in older individuals and associated with pathologic degeneration of the trabecular meshwork (TM). We have shown previously that transplantation of induced pluripotent stem cell (iPSC) derived TM cells restores aqueous humor dynamics in young transgenic mice expressing a pathogenic form of human myocilin (Tg-MYOCY437H). This study was designed to determine if this approach is feasible in older mice with more pronounced TM dysfunction.

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