Open AccessRat Limbal Niche Cells Prevent Epithelial Stem/Progenitor Cells From Differentiation and Proliferation by Inhibiting Notch Signaling Pathway In Vitro
Author(s) -
Jing Li,
SzuYu Chen,
Xinyue Zhao,
Mingchang Zhang,
Hua-Tao Xie
Publication year - 2017
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.16-20642
Subject(s) - microbiology and biotechnology , notch signaling pathway , progenitor cell , in vitro , niche , biology , stem cell , progenitor , signal transduction , genetics , biochemistry
Limbal niche cells (LNCs) play a pivotal role in regulating limbal epithelial stem/progenitor cells (LESCs). This study aimed to investigate whether Notch signaling is involved in LNCs' regulation of LESCs.
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