Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts | Zendy

Karl David Brown | Zendy; Manisha H. Shah | Zendy; GueiSheung Liu | Zendy; Elsa C. Chan | Zendy; Jonathan G. Crowston | Zendy; Hitesh Peshavariya | Zendy

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Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

Author(s) -

Karl David Brown,

Manisha H. Shah,

GueiSheung Liu,

Elsa C. Chan,

Jonathan G. Crowston,

Hitesh Peshavariya

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20633

Subject(s) - nox4 , nadph oxidase , transforming growth factor , chemistry , microbiology and biotechnology , wound healing , reactive oxygen species , biology , biochemistry , immunology

Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic scarring, and NADPH oxidase-derived reactive oxygen species has been shown to be an effector molecule that facilitates TGFβ1-mediated responses. The present study explores the expression profile and functional importance of NADPH oxidase (Nox) in conjunctival fibroblasts. In addition, the effect of curcumin on the TGFβ1-induced NADPH oxidase expression and collagen synthesis was also investigated.

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