ANRIL: A Regulator of VEGF in Diabetic Retinopathy | Zendy

Anu Thomas | Zendy; Biao Feng | Zendy; Subrata Chakrabarti | Zendy

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ANRIL: A Regulator of VEGF in Diabetic Retinopathy

Author(s) -

Anu Thomas,

Biao Feng,

Subrata Chakrabarti

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20569

Subject(s) - klf2 , prc2 , gene knockdown , diabetic retinopathy , gene silencing , retina , microbiology and biotechnology , small interfering rna , cancer research , biology , ezh2 , chemistry , downregulation and upregulation , rna , diabetes mellitus , gene expression , endocrinology , neuroscience , cell culture , genetics , gene

Long noncoding RNAs (lncRNAs) previously thought to be "dark matter" of the genome, play key roles in various biological processes. The lncRNA ANRIL is located at a genetic susceptibility locus for coronary artery diseases and type 2 diabetes. We examined the role of ANRIL in diabetic retinopathy, through study of its regulation of VEGF both in vitro and in vivo.

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