Open AccessRole of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy
Author(s) -
Yosuke Nagasaka,
Hiroki Kaneko,
Fuxiang Ye,
Shu Kachi,
Tetsu Asami,
Seiichi Kato,
Kei Takayama,
Shiang-Jyi Hwang,
Keiko Kataoka,
Hideyuki Shimizu,
Takeshi Iwase,
Yasuhito Funahashi,
Akiko Higuchi,
Takeshi Senga,
Hiroko Terasaki
Publication year - 2017
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.16-20513
Subject(s) - proliferative vitreoretinopathy , epithelial–mesenchymal transition , caveolin 1 , gene knockdown , pathogenesis , downregulation and upregulation , cancer research , cell migration , blot , microbiology and biotechnology , pathology , immunohistochemistry , mesenchymal stem cell , biology , cell , cell culture , retinal , medicine , retinal detachment , ophthalmology , biochemistry , genetics , gene
Proliferative vitreoretinopathy (PVR) is one of the most severe ocular diseases. Fibrotic changes in retinal cells are considered to be involved in the pathogenesis of PVR. Epithelial-mesenchymal transition (EMT) of RPE cells is one of the main concepts in the pathogenesis of fibrovascular membranes (FVMs) in PVR. In this study, we examined the expression of Caveolin-1 in human FVMs from patients with PVR. We also examined the role of Caveolin-1 in the pathogenesis of PVR.
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