Open AccessCompound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature
Author(s) -
Youde Jiang,
Li Liu,
Jena J. Steinle
Publication year - 2017
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.16-20412
Subject(s) - occludin , retinal , biology , vascular permeability , microbiology and biotechnology , tight junction , blot , endothelial stem cell , chemistry , endocrinology , biochemistry , in vitro , gene
To investigate whether Epac1 is key to Compound 49b's regulation of zonula occluden 1 (ZO-1) and occludin levels in human retinal endothelial cells (REC) and in an Epac1 vascular-specific conditional knockout mouse retina.
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