Association of High-Mobility Group Box-1 With Th Cell–Related Cytokines in the Vitreous of Ocular Sarcoidosis Patients | Zendy

Masaru Takeuchi | Zendy; Manzo Taguchi | Zendy; Tomohito Sato | Zendy; Kyoko Karasawa | Zendy; Yutaka Sakurai | Zendy; Kohzou Harimoto | Zendy; Masataka Ito | Zendy

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Association of High-Mobility Group Box-1 With Th Cell–Related Cytokines in the Vitreous of Ocular Sarcoidosis Patients

Author(s) -

Masaru Takeuchi,

Manzo Taguchi,

Tomohito Sato,

Kyoko Karasawa,

Yutaka Sakurai,

Kohzou Harimoto,

Masataka Ito

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20324

Subject(s) - proinflammatory cytokine , hmgb1 , medicine , sarcoidosis , vitrectomy , high mobility group , diabetic retinopathy , interleukin , inflammation , immunology , cytokine , ophthalmology , endocrinology , chemistry , diabetes mellitus , visual acuity , biochemistry , gene

High-mobility group box-1 (HMGB1) is a nonhistone DNA-binding nuclear protein released from necrotic cells, which is also secreted by activated leukocytes and acts as a primary proinflammatory cytokine. In this study, we compared vitreous HMGB1 levels in ocular sarcoidosis with those in noninflammatory vitreoretinal diseases and evaluated its association with Th cell-related and proinflammatory cytokines.

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