Evaluation of Therapeutic Tissue Crosslinking (TXL) for Myopia Using Second Harmonic Generation Signal Microscopy in Rabbit Sclera | Zendy

Mariya Zyablitskaya | Zendy; Anna Takaoka | Zendy; Emilia Laura Munteanu | Zendy; Takayuki Nagasaki | Zendy; Stephen L. Trokel | Zendy; David C. Paik | Zendy

Open Access

Evaluation of Therapeutic Tissue Crosslinking (TXL) for Myopia Using Second Harmonic Generation Signal Microscopy in Rabbit Sclera

Author(s) -

Mariya Zyablitskaya,

Anna Takaoka,

Emilia Laura Munteanu,

Takayuki Nagasaki,

Stephen L. Trokel,

David C. Paik

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20241

Subject(s) - sclera , materials science , cornea , microscopy , biomedical engineering , elastin , optics , ophthalmology , medicine , pathology , physics

Second harmonic generation signals (SHG) are emitted preferentially from collagenous tissue structures and have been used to evaluate photochemically-induced (CXL) crosslinking changes in the cornea. Since therapeutic tissue crosslinking (TXL) using sodium hydroxymethylglycinate (SMG) of the sclera is a potential treatment for high myopia, we explored the use of SHG microscopy to evaluate the effects.

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