MicroRNA Expression Patterns Involved in Amyloid Beta–Induced Retinal Degeneration | Zendy

Peirong Huang | Zendy; Junran Sun | Zendy; Fenghua Wang | Zendy; Xueting Luo | Zendy; Qing Gu | Zendy; Te Liu | Zendy; Xiaodong Sun | Zendy

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MicroRNA Expression Patterns Involved in Amyloid Beta–Induced Retinal Degeneration

Author(s) -

Peirong Huang,

Junran Sun,

Fenghua Wang,

Xueting Luo,

Qing Gu,

Te Liu,

Xiaodong Sun

Publication year - 2017

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20043

Subject(s) - microrna , retinal pigment epithelium , retina , biology , retinal , h&e stain , retinal degeneration , pathology , gene expression profiling , microbiology and biotechnology , drusen , downregulation and upregulation , gene expression , staining , gene , genetics , medicine , neuroscience , biochemistry

Dry age-related macular degeneration (AMD) is characterized by the accumulation of drusen under Bruch's membrane, and amyloid beta (Aβ) is speculated to be one of the key pathologic factors. While the detrimental effects of Aβ on retinas have been widely explored, Aβ-induced epigenetic regulatory changes have yet to be fully investigated. We therefore aimed to identify the microRNA (miRNA) expression profiles in an Aβ-induced mouse model of retinal degeneration.

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