Activation of Rac1 and RhoA Preserve Corneal Endothelial Barrier Function | Zendy

María Cristina Ortega | Zendy; Diana SantanderGarcía | Zendy; Beatriz MarcosRamiro | Zendy; Susana Barroso | Zendy; Susan Cox | Zendy; Ignacio Jiménez-Alfaro | Zendy; Jaime Millán | Zendy

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Activation of Rac1 and RhoA Preserve Corneal Endothelial Barrier Function

Author(s) -

María Cristina Ortega,

Diana SantanderGarcía,

Beatriz MarcosRamiro,

Susana Barroso,

Susan Cox,

Ignacio Jiménez-Alfaro,

Jaime Millán

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-20031

Subject(s) - rhoa , microbiology and biotechnology , cdc42 , rac1 , barrier function , endothelial stem cell , chemistry , stress fiber , endothelium , biology , gtpase , signal transduction , in vitro , biochemistry , focal adhesion , endocrinology

The corneal endothelium is responsible for the correct hydration of the corneal stroma. Corneal endothelial cells have a low proliferative capacity, so preserving their barrier function under suboptimal conditions that cause osmotic imbalance, such as those arising from corneal pathologies, age, cryopreservation, and transplantation, is essential for maintaining corneal transparency. We have investigated the signaling induced by hyperosmotic shock that reversibly disrupts corneal endothelial barriers in human endothelial cells and in murine corneas.

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