Loss of Melanopsin-Expressing Retinal Ganglion Cells in Severely Staged Glaucoma Patients | Zendy

Elisabeth Anne Adanma Obara | Zendy; Jens Hannibal | Zendy; Steffen Heegaard | Zendy; Jan Fahrenkrug | Zendy

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Loss of Melanopsin-Expressing Retinal Ganglion Cells in Severely Staged Glaucoma Patients

Author(s) -

Elisabeth Anne Adanma Obara,

Jens Hannibal,

Steffen Heegaard,

Jan Fahrenkrug

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19997

Subject(s) - melanopsin , glaucoma , retina , retinal ganglion cell , retinal , ophthalmology , ganglion cell layer , biology , ganglion , inner nuclear layer , intrinsically photosensitive retinal ganglion cells , pathology , medicine , anatomy , neuroscience , photopigment

Multiple studies have shown overwhelming evidence supporting the impairment of melanopsin function due to glaucoma. However, few studies have been carried out in humans analyzing the histology of melanopsin-expressing retinal ganglion cells (mRGCs) in retinas with glaucoma. The aim of this study was to analyze the pattern of expression of mRGCs relative to RGCs in the normal retina and retinas harboring varying stages of glaucoma.

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