Short-term Alteration of Developmental Neural Activity Enhances Neurite Outgrowth of Retinal Explants | Zendy

MengJung Lee | Zendy; ChuanChin Chiao | Zendy

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Short-term Alteration of Developmental Neural Activity Enhances Neurite Outgrowth of Retinal Explants

Author(s) -

MengJung Lee,

ChuanChin Chiao

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19854

Subject(s) - neurite , retinal , neuroscience , retina , neurotrophic factors , biology , retinal waves , axon , neurotrophin , stimulation , microbiology and biotechnology , retinal ganglion cell , intrinsically photosensitive retinal ganglion cells , in vitro , receptor , biochemistry

It is well known that the gradual loss of axon growth ability of retinal ganglion cells (RGCs) during development is largely determined by extrinsic signals rather than being programmed intrinsically. Spontaneous retinal waves are the major neural activity during retinal development. Thus restoring the developmental environment by providing the proper neural activity may be able to help axon regeneration of RGCs.

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