Open AccessSomatic Variants in the Human Lens Epithelium: A Preliminary Assessment
Author(s) -
Rosana A. Mesa,
Manoj Tyagi,
George J. Harocopos,
David Vollman,
Steven Bassnett
Publication year - 2016
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.16-19726
Subject(s) - biology , somatic cell , genetics , germline , lens (geology) , dna sequencing , gene , allele , microbiology and biotechnology , paleontology
We hypothesize that somatic mutations accumulate in cells of the human lens and may contribute to the development of cortical or posterior sub-capsular cataracts. Here, we used a Next-generation sequencing (NGS) strategy to screen for low-allelic frequency variants in DNA extracted from human lens epithelial samples.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom