Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion | Zendy

Wahiba HadjSaïd | Zendy; Nicolas Froger | Zendy; Ivana Ivković | Zendy; Manuel Jiménez-López | Zendy; Élisabeth Dubus | Zendy; Julie Dégardin-Chicaud | Zendy; Manuel Simonutti | Zendy; Quénol Cesar | Zendy; N. Neveux | Zendy; María Paz VillegasPérez | Zendy; Marta AgudoBarriuso | Zendy; Manuel VidalSanz | Zendy; JoséAlain Sahel | Zendy; Serge Picaud | Zendy; Diego GarcíaAyuso | Zendy

Open Access

Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion

Author(s) -

Wahiba HadjSaïd,

Nicolas Froger,

Ivana Ivković,

Manuel Jiménez-López,

Élisabeth Dubus,

Julie Dégardin-Chicaud,

Manuel Simonutti,

Quénol Cesar,

N. Neveux,

María Paz VillegasPérez,

Marta AgudoBarriuso,

Manuel VidalSanz,

JoséAlain Sahel,

Serge Picaud,

Diego GarcíaAyuso

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19535

Subject(s) - retina , opsin , retinal , taurine , biology , erg , electroretinography , retinal degeneration , retinal ganglion cell , ganglion , anatomy , microbiology and biotechnology , neuroscience , rhodopsin , biochemistry , amino acid

Taurine depletion is known to induce photoreceptor degeneration and was recently found to also trigger retinal ganglion cell (RGC) loss similar to the retinal toxicity of vigabatrin. Our objective was to study the topographical loss of RGCs and cone photoreceptors, with a distinction between the two cone types (S- and L- cones) in an animal model of induced taurine depletion.

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