Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure | Zendy

Sally Miller | Zendy; Emma Leishman | Zendy; Olivia Oehler | Zendy; Laura Daily | Zendy; Natalia Murataeva | Zendy; Jim WagerMiller | Zendy; Heather B. Bradshaw | Zendy; Alex Straiker | Zendy

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Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure

Author(s) -

Sally Miller,

Emma Leishman,

Olivia Oehler,

Laura Daily,

Natalia Murataeva,

Jim WagerMiller,

Heather B. Bradshaw,

Alex Straiker

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19437

Subject(s) - anandamide , intraocular pressure , endocannabinoid system , fatty acid amide hydrolase , pharmacology , endocrinology , medicine , biology , chemistry , agonist , biochemistry , cannabinoid receptor , receptor , ophthalmology

The diurnal cycling of intraocular pressure (IOP) was first described in humans more than a century ago. This cycling is preserved in other species. The physiologic underpinning of this diurnal variation in IOP remains a mystery, even though elevated pressure is indicated in most forms of glaucoma, a common cause of blindness. Once identified, the system that underlies diurnal variation would represent a natural target for therapeutic intervention.

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