AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo | Zendy

Sandy Hung | Zendy; Vicki Chrysostomou | Zendy; Li Fan | Zendy; Jeremiah K. H. Lim | Zendy; Jiang-Hui Wang | Zendy; Joseph E. Powell | Zendy; Leilei Tu | Zendy; Maciej Daniszewski | Zendy; Camden Lo | Zendy; Raymond C.B. Wong | Zendy; Jonathan G. Crowston | Zendy; Alice Pébay | Zendy; Anna E. King | Zendy; Bang V. Bui | Zendy; GueiSheung Liu | Zendy; Alex W. Hewitt | Zendy

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AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo

Author(s) -

Sandy Hung,

Vicki Chrysostomou,

Li Fan,

Jeremiah K. H. Lim,

Jiang-Hui Wang,

Joseph E. Powell,

Leilei Tu,

Maciej Daniszewski,

Camden Lo,

Raymond C.B. Wong,

Jonathan G. Crowston,

Alice Pébay,

Anna E. King,

Bang V. Bui,

GueiSheung Liu,

Alex W. Hewitt

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19316

Subject(s) - crispr , biology , genome editing , yellow fluorescent protein , retinal , transgene , cas9 , adeno associated virus , subgenomic mrna , genetic enhancement , microbiology and biotechnology , gene , genetics , vector (molecular biology) , recombinant dna , biochemistry

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein (Cas) has recently been adapted to enable efficient editing of the mammalian genome, opening novel avenues for therapeutic intervention of inherited diseases. In seeking to disrupt yellow fluorescent protein (YFP) in a Thy1-YFP transgenic mouse, we assessed the feasibility of utilizing the adeno-associated virus 2 (AAV2) to deliver CRISPR/Cas for gene modification of retinal cells in vivo.

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