Intravitreal Injection of Proinsulin-Loaded Microspheres Delays Photoreceptor Cell Death and Vision Loss in therd10Mouse Model of Retinitis Pigmentosa | Zendy

Carolina Isiegas | Zendy; Jorge A. Marinich-Madzarevich | Zendy; Miguel Marchena | Zendy; José María Ruiz | Zendy; María J. Cano | Zendy; Pedro de la Villa | Zendy; Catalina HernándezSánchez | Zendy; Enrique J. de la Rosa | Zendy; Flora de Pablo | Zendy

Open Access

Intravitreal Injection of Proinsulin-Loaded Microspheres Delays Photoreceptor Cell Death and Vision Loss in therd10Mouse Model of Retinitis Pigmentosa

Author(s) -

Carolina Isiegas,

Jorge A. Marinich-Madzarevich,

Miguel Marchena,

José María Ruiz,

María J. Cano,

Pedro de la Villa,

Catalina HernándezSánchez,

Enrique J. de la Rosa,

Flora de Pablo

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19300

Subject(s) - retinitis pigmentosa , outer nuclear layer , photoreceptor cell , electroretinography , retina , retinal , retinal degeneration , neuroprotection , biology , ophthalmology , medicine , pharmacology , neuroscience

The induction of proinsulin expression by transgenesis or intramuscular gene therapy has been shown previously to retard retinal degeneration in mouse and rat models of retinitis pigmentosa (RP), a group of inherited conditions that result in visual impairment. We investigated whether intraocular treatment with biodegradable poly (lactic-co-glycolic) acid microspheres (PLGA-MS) loaded with proinsulin has cellular and functional neuroprotective effects in the retina.

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