Open AccessDystrophin Is Required for Proper Functioning of Luminance and Red–Green Cone Opponent Mechanisms in the Human Retina
Author(s) -
Mirella Telles Salgueiro Barboni,
Cristiane Maria Gomes Martins,
Balázs Vince Nagy,
Tina I. Tsai,
Francisco Max Damico,
Marcelo Fernandes Costa,
Rita de Cássia,
Marco Pavanello,
Naila Cristina Vilaça Lourenço,
Antonia Cerqueira,
Mayana Zatz,
Jan Kremers,
Dora Fix Ventura
Publication year - 2016
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.16-19287
Subject(s) - photopic vision , scotopic vision , retina , retinal , electroretinography , neuroscience , erg , biology , luminance , dystrophin , anatomy , duchenne muscular dystrophy , ophthalmology , medicine , physics , optics , genetics
Visual information is processed in parallel pathways in the visual system. Parallel processing begins at the synapse between the photoreceptors and their postreceptoral neurons in the human retina. The integrity of this first neural connection is vital for normal visual processing downstream. Of the numerous elements necessary for proper functioning of this synaptic contact, dystrophin proteins in the eye play an important role. Deficiency of muscle dystrophin causes Duchenne muscular dystrophy (DMD), an X-linked disease that affects muscle function and leads to decreased life expectancy. In DMD patients, postreceptoral retinal mechanisms underlying scotopic and photopic vision and ON- and OFF-pathway responses are also altered.
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