Netrin-4 Mediates Corneal Hemangiogenesis but Not Lymphangiogenesis in the Mouse-Model of Suture-Induced Neovascularization
Author(s) -
Anna-Karina B. Maier,
S. Klein,
Norbert Kociok,
Aline I. Riechardt,
Enken Gundlach,
Nadine Reichhart,
Olaf Strauß,
Antonia M. Joussen
Publication year - 2017
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.16-19249
Subject(s) - lymphangiogenesis , corneal neovascularization , netrin , fibrous joint , neovascularization , medicine , ophthalmology , microbiology and biotechnology , cancer research , angiogenesis , anatomy , biology , cancer , metastasis , axon , axon guidance
Netrin-4, a secreted protein, is found in the basement membrane of blood vessels and acts as a key regulator of angiogenesis. Here we investigated the role of Netrin-4 in the mouse-model of suture-induced corneal hem- and lymphangiogenesis.
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