Upregulation of Transient Receptor Potential Vanilloid Type-1 Channel Activity and Ca2+Influx Dysfunction in Human Pterygial Cells | Zendy

Fabian Garreis | Zendy; Antje Schröder | Zendy; Peter S. Reinach | Zendy; Stefanie Zoll | Zendy; Noushafarin Khajavi | Zendy; Priyavathi Dhandapani | Zendy; Alexander Lucius | Zendy; Uwe Pleyer | Zendy; Friedrich Paulsen | Zendy; Stefan Mergler | Zendy

Open Access

Upregulation of Transient Receptor Potential Vanilloid Type-1 Channel Activity and Ca²⁺Influx Dysfunction in Human Pterygial Cells

Author(s) -

Fabian Garreis,

Antje Schröder,

Peter S. Reinach,

Stefanie Zoll,

Noushafarin Khajavi,

Priyavathi Dhandapani,

Alexander Lucius,

Uwe Pleyer,

Friedrich Paulsen,

Stefan Mergler

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.16-19170

Subject(s) - capsazepine , trpv1 , transient receptor potential channel , capsaicin , chemistry , downregulation and upregulation , cell growth , microbiology and biotechnology , receptor , pharmacology , biology , biochemistry , gene

The heat-sensitive transient receptor potential vanilloid type-1 (TRPV1) channel (i.e., capsaicin [CAP] receptor) is upregulated in numerous cancers. This study determined if this response occurs in fresh and cultured hyperplastic human pterygial epithelial tissues.

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