Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor | Zendy

Shinichi Otani | Zendy; Taiji Nagaoka | Zendy; Tsuneaki Omae | Zendy; Ichiro Tanano | Zendy; Takayuki Kamiya | Zendy; Shinji Ono | Zendy; Travis W. Hein | Zendy; Lih Kuo | Zendy; Akitoshi Yoshida | Zendy

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Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor

Author(s) -

Shinichi Otani,

Taiji Nagaoka,

Tsuneaki Omae,

Ichiro Tanano,

Takayuki Kamiya,

Shinji Ono,

Travis W. Hein,

Lih Kuo,

Akitoshi Yoshida

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-19038

Subject(s) - histamine , dilation (metric space) , retinal , chemistry , ophthalmology , medicine , mathematics , combinatorics

Although endothelium-dependent nitric oxide (NO)-mediated dilation of retinal arterioles has been well described, the role of endothelium-derived hyperpolarizing factor (EDHF) in the retinal arteriolar response remains unclear. In the current study, we examined the contribution of EDHF to the retinal arteriolar dilation to the inflammatory agent histamine and investigated the signaling mechanisms underlying this vasomotor activity.

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