DNA Duplex-Based Photodynamic Molecular Beacon for Targeted Killing of Retinoblastoma Cell | Zendy

Yanchun Wei | Zendy; Cuixia Lu | Zendy; Qun Chen | Zendy; Da Xing | Zendy

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DNA Duplex-Based Photodynamic Molecular Beacon for Targeted Killing of Retinoblastoma Cell

Author(s) -

Yanchun Wei,

Cuixia Lu,

Qun Chen,

Da Xing

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18723

Subject(s) - mdmx , molecular beacon , photodynamic therapy , photosensitizer , oligonucleotide , retinoblastoma , flow cytometry , microbiology and biotechnology , dna , chemistry , cancer research , biology , biochemistry , gene , mdm2 , photochemistry , organic chemistry

Retinoblastoma (RB) is the most common primary intraocular malignancy of infancy. An alternative RB treatment protocol is proposed and tested. It is based on a photodynamic therapy (PDT) with a designed molecular beacon that specifically targets the murine double minute x (MDMX) high-expressed RB cells.

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