Measuring In Vivo Free Radical Production by the Outer Retina | Zendy

Bruce A. Berkowitz | Zendy; Bryce X. Bredell | Zendy; Christopher R. Davis | Zendy; Marijana Samardzija | Zendy; Christian Grimm | Zendy; Robin Roberts | Zendy

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Measuring In Vivo Free Radical Production by the Outer Retina

Author(s) -

Bruce A. Berkowitz,

Bryce X. Bredell,

Christopher R. Davis,

Marijana Samardzija,

Christian Grimm,

Robin Roberts

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18420

Subject(s) - retinal , in vivo , retina , oxidative stress , ex vivo , chemistry , visual phototransduction , biophysics , medicine , endocrinology , pathology , ophthalmology , biology , biochemistry , neuroscience , microbiology and biotechnology

Excessive and continuously produced free radicals in the outer retina are implicated in retinal aging and the pathogenesis of sight-threatening retinopathies, yet measuring outer retinal oxidative stress in vivo remains a challenge. Here, we test the hypothesis that continuously produced paramagnetic free radicals from the outer retina can be measured in vivo using high-resolution (22-μm axial resolution) 1/T1magnetic resonance imaging (MRI) without and with a confirmatory quench (quench-assisted MRI).

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