Hyperosmolar Tears Induce Functional and Structural Alterations of Corneal Nerves: Electrophysiological and Anatomical Evidence Toward Neurotoxicity | Zendy

Harumitsu Hirata | Zendy; Kamila Mizerska | Zendy; Carl F. Marfurt | Zendy; Mark I. Rosenblatt | Zendy

Open Access

Hyperosmolar Tears Induce Functional and Structural Alterations of Corneal Nerves: Electrophysiological and Anatomical Evidence Toward Neurotoxicity

Author(s) -

Harumitsu Hirata,

Kamila Mizerska,

Carl F. Marfurt,

Mark I. Rosenblatt

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18383

Subject(s) - tears , cornea , corneal reflex , medicine , artificial tears , electrophysiology , ophthalmology , ganglion , anatomy , population , reflex , anesthesia , physiology , surgery , environmental health

In an effort to elucidate possible neural mechanisms underlying diminished tearing in dry eye disease, this study sought to determine if hyperosmolar tears, a ubiquitous sign of dry eye disease, produce functional changes in corneal nerve responses to drying of the cornea and if these changes correlate with alterations in corneal nerve morphology.

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