Defective Myogenic Response of Retinal Vessels Is Associated With Accelerated Onset of Retinopathy in Type 1 Diabetic Individuals | Zendy

Francesco Tecilazich | Zendy; Gilbert T. Feke | Zendy; S Mazzantini | Zendy; Lucia Sobrin | Zendy; Mara Lorenzi | Zendy

Open Access

Defective Myogenic Response of Retinal Vessels Is Associated With Accelerated Onset of Retinopathy in Type 1 Diabetic Individuals

Author(s) -

Francesco Tecilazich,

Gilbert T. Feke,

S Mazzantini,

Lucia Sobrin,

Mara Lorenzi

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18356

Subject(s) - myogenic contraction , diabetic retinopathy , medicine , retinopathy , retinal , blood pressure , perfusion , diabetes mellitus , ophthalmology , retina , cardiology , hemodynamics , endocrinology , biology , neuroscience , smooth muscle

We seek to identify pathogenic mechanisms for diabetic retinopathy that can become therapeutic targets beyond hyperglycemia and hypertension. We investigated if a defective myogenic response of retinal arteries to increased perfusion pressure, which exposes capillaries to increased pressure and flow, is associated with the onset of clinical retinopathy.

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