Corneal Expression of SLURP-1 by Age, Sex, Genetic Strain, and Ocular Surface Health | Zendy

Sudha Swamynathan | Zendy; Emili E. Delp | Zendy; S. Harvey | Zendy; Chelsea L. Loughner | Zendy; Leela Raju | Zendy; Shivalingappa K. Swamynathan | Zendy

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Corneal Expression of SLURP-1 by Age, Sex, Genetic Strain, and Ocular Surface Health

Author(s) -

Sudha Swamynathan,

Emili E. Delp,

S. Harvey,

Chelsea L. Loughner,

Leela Raju,

Shivalingappa K. Swamynathan

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18206

Subject(s) - strain (injury) , ophthalmology , medicine , biology , anatomy

Although secreted Ly6/urokinase-type plasminogen activator receptor-related protein-1 (Slurp1) transcript is highly abundant in the mouse cornea, corresponding protein expression remains uncharacterized. Also, SLURP1 was undetected in previous tear proteomics studies, resulting in ambiguity about its baseline levels. Here, we examine mouse corneal Slurp1 expression in different sexes, age groups, strains, and health conditions, and quantify SLURP1 in human tears from healthy or inflamed ocular surfaces.

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