Anti-Inflammatory Effect of Dexamethasone Controlled Released From Anterior Suprachoroidal Polyurethane Implants on Endotoxin-Induced Uveitis in Rats | Zendy

Juliana Barbosa Saliba | Zendy; Lorena Carla Vieira | Zendy; Gabriella Maria Fernandes-Cunha | Zendy; Gisele Rodrigues da Silva | Zendy; Sílvia Ligório Fialho | Zendy; Armando SilvaCunha | Zendy; Elodie Bousquet | Zendy; MarieChristine Naud | Zendy; Eliane Ayres | Zendy; Rodrigo Lambert Oréfice | Zendy; M. Tekaya | Zendy; Laura Kowalczuk | Zendy; Min Zhao | Zendy; Francine BéharCohen | Zendy

Open Access

Anti-Inflammatory Effect of Dexamethasone Controlled Released From Anterior Suprachoroidal Polyurethane Implants on Endotoxin-Induced Uveitis in Rats

Author(s) -

Juliana Barbosa Saliba,

Lorena Carla Vieira,

Gabriella Maria Fernandes-Cunha,

Gisele Rodrigues da Silva,

Sílvia Ligório Fialho,

Armando SilvaCunha,

Elodie Bousquet,

MarieChristine Naud,

Eliane Ayres,

Rodrigo Lambert Oréfice,

M. Tekaya,

Laura Kowalczuk,

Min Zhao,

Francine BéharCohen

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18127

Subject(s) - proinflammatory cytokine , dexamethasone , uveitis , chemokine , cytokine , ciliary body , implant , medicine , pharmacology , inflammation , chemistry , immunology , ophthalmology , surgery

Targeted drug delivery to the ocular tissues remains a challenge. Biodegradable intraocular implants allow prolonged controlled release of drugs directly into the eye. In this study, we evaluated an anterior suprachoroidal polyurethane implant containing dexamethasone polyurethane dispersions (DX-PUD) as a drug delivery system in the rat model of endotoxin-induced uveitis (EIU).

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