Effects of Insulin and High Glucose on Human Meibomian Gland Epithelial Cells | Zendy

Juan Ding | Zendy; Yang Liu | Zendy; David A. Sullivan | Zendy

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Effects of Insulin and High Glucose on Human Meibomian Gland Epithelial Cells

Author(s) -

Juan Ding,

Yang Liu,

David A. Sullivan

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-18049

Subject(s) - medicine , endocrinology , insulin , insulin resistance , protein kinase b , insulin receptor , biology , foxo1 , growth factor , type 2 diabetes , receptor , diabetes mellitus , signal transduction , microbiology and biotechnology

Type 2 diabetes is a risk factor for meibomian gland dysfunction (MGD). We hypothesize that this diabetic impact is due, at least in part, to the effects of insulin resistance/deficiency and hyperglycemia on human meibomian gland epithelial cells (HMGECs). To begin to test this hypothesis, we examined whether insulin and high glucose influence immortalized (I) HMGECs.

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