Open AccessEffects of Insulin and High Glucose on Human Meibomian Gland Epithelial Cells
Author(s) -
Juan Ding,
Yang Liu,
David A. Sullivan
Publication year - 2015
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.15-18049
Subject(s) - medicine , endocrinology , insulin , insulin resistance , protein kinase b , insulin receptor , biology , foxo1 , growth factor , type 2 diabetes , receptor , diabetes mellitus , signal transduction , microbiology and biotechnology
Type 2 diabetes is a risk factor for meibomian gland dysfunction (MGD). We hypothesize that this diabetic impact is due, at least in part, to the effects of insulin resistance/deficiency and hyperglycemia on human meibomian gland epithelial cells (HMGECs). To begin to test this hypothesis, we examined whether insulin and high glucose influence immortalized (I) HMGECs.