Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport | Zendy

David Kleesattel | Zendy; Samuel D. Crish | Zendy; Denise M. Inman | Zendy

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Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport

Author(s) -

David Kleesattel,

Samuel D. Crish,

Denise M. Inman

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17885

Subject(s) - mitophagy , axoplasmic transport , axon , autophagy , microbiology and biotechnology , mitochondrion , optic nerve , biology , axon terminal , chemistry , neuroscience , biochemistry , apoptosis

Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally differentiated cells like neurons manage cytoskeletal and organelle turnover. How autophagy relates to associated neurodegenerative pathologies remain unclear. We examined autophagy in optic neuropathy by investigating cytoskeletal degradation, mitochondria, and autophagic vesicles in the DBA2/J mouse model of glaucoma exhibiting differing levels of axon transport functionality.

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