Arrestin 1 and Cone Arrestin 4 Have Unique Roles in Visual Function in an All-Cone Mouse Retina | Zendy

Janise D. Deming | Zendy; Joseph S. Pak | Zendy; JungA Shin | Zendy; B. M. Brown | Zendy; Moon Kim | Zendy; Moe H. Aung | Zendy; Eun Jin Lee | Zendy; Machelle T. Pardue | Zendy; Cheryl M. Craft | Zendy

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Arrestin 1 and Cone Arrestin 4 Have Unique Roles in Visual Function in an All-Cone Mouse Retina

Author(s) -

Janise D. Deming,

Joseph S. Pak,

JungA Shin,

B. M. Brown,

Moon Kim,

Moe H. Aung,

Eun Jin Lee,

Machelle T. Pardue,

Cheryl M. Craft

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17832

Subject(s) - visual phototransduction , opsin , photopic vision , retina , biology , electroretinography , erg , retinal , adaptation (eye) , rhodopsin , neuroscience , biochemistry

Previous studies discovered cone phototransduction shutoff occurs normally for Arr1-/- and Arr4-/-; however, it is defective when both visual arrestins are simultaneously not expressed (Arr1-/-Arr4-/-). We investigated the roles of visual arrestins in an all-cone retina (Nrl-/-) since each arrestin has differential effects on visual function, including ARR1 for normal light adaptation, and ARR4 for normal contrast sensitivity and visual acuity.

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