Phenotypic Change and Induction of Cytokeratin Expression During In Vitro Culture of Corneal Stromal Cells | Zendy

Laura E. Sidney | Zendy; Owen D. McIntosh | Zendy; Andrew Hopkinson | Zendy

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Phenotypic Change and Induction of Cytokeratin Expression During In Vitro Culture of Corneal Stromal Cells

Author(s) -

Laura E. Sidney,

Owen D. McIntosh,

Andrew Hopkinson

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17810

Subject(s) - cytokeratin , stromal cell , phenotype , in vitro , biology , pathology , microbiology and biotechnology , immunology , medicine , immunohistochemistry , cancer research , genetics , gene

Cells of the corneal epithelium and stroma can be distinguished in vivo by different intermediate filaments, cytokeratins for corneal epithelial cells (CEC) and vimentin for keratocytes. Isolated and cultured keratocytes change phenotype, losing expression of keratocyte markers and gaining markers associated with mesenchymal stromal cells (MSC). This study investigates this change in phenotype in relation to intermediate filament expression in cultured corneal stromal cells (CSC) compared to CEC.

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