Temporal Properties of Cone ERGs of Pikachurin Null Mutant Mouse | Zendy

Taro Kominami | Zendy; Shinji Ueno | Zendy; Ayami Nakanishi | Zendy; Azusa Kominami | Zendy; Mineo Kondo | Zendy; Takahisa Furukawa | Zendy; Hiroko Terasaki | Zendy

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Temporal Properties of Cone ERGs of Pikachurin Null Mutant Mouse

Author(s) -

Taro Kominami,

Shinji Ueno,

Ayami Nakanishi,

Azusa Kominami,

Mineo Kondo,

Takahisa Furukawa,

Hiroko Terasaki

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17708

Subject(s) - biology , electroretinography , metabotropic glutamate receptor 6 , stimulation , flicker , retina , chemistry , microbiology and biotechnology , neuroscience , glutamate receptor , biochemistry , metabotropic glutamate receptor , receptor , electrical engineering , engineering

Pikachurin is an extracellular matrix-like protein located in the synaptic cleft of photoreceptors. Pikachurin null mutant (Pika-/-) mice have abnormal ON bipolar cell function. This study aimed to determine the contribution of the ON bipolar cell pathway (ON pathway) of Pika-/- mice to the flicker ERG response and, using vector analysis, identify how the contribution varies with the stimulus frequency.

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