N-Ethylmaleimide–Sensitive Factor b (nsfb) Is Required for Normal Pigmentation of the Zebrafish Retinal Pigment Epithelium | Zendy

Nicholas J. Hanovice | Zendy; Christina M. Daly | Zendy; Jeffrey M. Gross | Zendy

Open Access

N-Ethylmaleimide–Sensitive Factor b (nsfb) Is Required for Normal Pigmentation of the Zebrafish Retinal Pigment Epithelium

Author(s) -

Nicholas J. Hanovice,

Christina M. Daly,

Jeffrey M. Gross

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17704

Subject(s) - biology , zebrafish , microbiology and biotechnology , genetics , retinal pigment epithelium , mutant , complementation , gene , mutation , nonsense mutation , melanosome , single nucleotide polymorphism , retinal , missense mutation , genotype , melanin , biochemistry

Despite the number of albinism-causing mutations identified in human patients and animal models, there remain a significant number of cases for which no mutation has been identified, suggesting that our understanding of melanogenesis is incomplete. Previously, we identified two oculocutaneous albinism mutations in zebrafish, au13 and au18. Here, we sought to identify the mutated loci and determine how the affected proteins contribute to normal pigmentation of the retinal pigment epithelium (RPE).

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