Profiling of Cytokines Secreted by Conventional Aqueous Outflow Pathway Endothelial Cells Activated In Vitro and Ex Vivo With Laser Irradiation | Zendy

Jorge A. Alvarado | Zendy; Phuonglan Chau | Zendy; Jianfeng Wu | Zendy; Richard P. Juster | Zendy; Amde Selassie Shifera | Zendy; Michael J. Geske | Zendy

Open Access

Profiling of Cytokines Secreted by Conventional Aqueous Outflow Pathway Endothelial Cells Activated In Vitro and Ex Vivo With Laser Irradiation

Author(s) -

Jorge A. Alvarado,

Phuonglan Chau,

Jianfeng Wu,

Richard P. Juster,

Amde Selassie Shifera,

Michael J. Geske

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17660

Subject(s) - downregulation and upregulation , ex vivo , cytokine , in vivo , receptor , chemistry , microbiology and biotechnology , immunology , biology , gene , biochemistry

To profile which cytokine genes are differentially expressed (DE) as up- or downregulated by cultured human trabecular meshwork (TMEs) and Schlemm's canal endothelial cells (SCEs) after three experimental treatments consisting of selective laser trabeculoplasty (SLT) irradiation, exposure to media conditioned either by SLT-irradiated TMEs (TME-cm) or by SCEs (SCE-cm). Also, to profile which cytokines are upregulated ex vivo in SLT-irradiated human conventional aqueous outflow pathway (CAOP) tissues.

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