The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling | Zendy

Scott M. Taylor | Zendy; Karen Álvarez-Delfín | Zendy; Carole J. Saade | Zendy; Jennifer L. Thomas | Zendy; Ryan Thummel | Zendy; James M. Fadool | Zendy; Peter F. Hitchcock | Zendy

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The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling

Author(s) -

Scott M. Taylor,

Karen Álvarez-Delfín,

Carole J. Saade,

Jennifer L. Thomas,

Ryan Thummel,

James M. Fadool,

Peter F. Hitchcock

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17616

Subject(s) - neurod , biology , notch signaling pathway , gene knockdown , microbiology and biotechnology , genetics , transcription factor , signal transduction , gene

Photoreceptor genesis in the retina requires precise regulation of progenitor cell competence, cell cycle exit, and differentiation, although information around the mechanisms that govern these events currently is lacking. In zebrafish, the basic helix-loop-helix (bHLH) transcription factor NeuroD governs photoreceptor genesis, but the signaling pathways through which NeuroD functions are unknown. The purpose of this study was to identify these pathways, and during photoreceptor genesis, Notch signaling was investigated as the putative mediator of NeuroD function.

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