Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma inCol4a1Mutant Mice | Zendy

Mao Mao | Zendy; Richard S. Smith | Zendy; Marcel V. Alavi | Zendy; Jeffrey K. Marchant | Zendy; Mihai Cosma | Zendy; Richard T. Libby | Zendy; Simon W. M. John | Zendy; Douglas B. Gould | Zendy

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Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma inCol4a1Mutant Mice

Author(s) -

Mao Mao,

Richard S. Smith,

Marcel V. Alavi,

Jeffrey K. Marchant,

Mihai Cosma,

Richard T. Libby,

Simon W. M. John,

Douglas B. Gould

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17527

Subject(s) - dysgenesis , penetrance , context (archaeology) , glaucoma , mutant , optic nerve , biology , mutation , phenotype , genetics , retinal ganglion cell , ophthalmology , pathology , medicine , anatomy , gene , neuroscience , paleontology

Mutations in the gene encoding collagen type IV alpha 1 (COL4A1) cause multisystem disorders including anterior segment dysgenesis (ASD) and optic nerve hypoplasia. The penetrance and severity of individual phenotypes depends on genetic context. Here, we tested the effects of a Col4a1 mutation in two different genetic backgrounds to compare how genetic context influences ocular dysgenesis, IOP, and progression to glaucoma.

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