siRNA-Mediated Knockdown of the mTOR Inhibitor RTP801 Promotes Retinal Ganglion Cell Survival and Axon Elongation by Direct and Indirect Mechanisms | Zendy

Peter Morgan-Warren | Zendy; Jenna O'Neill | Zendy; Felicity de Cogan | Zendy; Igor Spivak | Zendy; Hagit Ashush | Zendy; Hagar Kalinski | Zendy; Zubair Ahmed | Zendy; Martin Berry | Zendy; Elena Feinstein | Zendy; Robert A. H. Scott | Zendy; Ann Logan | Zendy

Open Access

siRNA-Mediated Knockdown of the mTOR Inhibitor RTP801 Promotes Retinal Ganglion Cell Survival and Axon Elongation by Direct and Indirect Mechanisms

Author(s) -

Peter Morgan-Warren,

Jenna O'Neill,

Felicity de Cogan,

Igor Spivak,

Hagit Ashush,

Hagar Kalinski,

Zubair Ahmed,

Martin Berry,

Elena Feinstein,

Robert A. H. Scott,

Ann Logan

Publication year - 2016

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17511

Subject(s) - neurite , retinal ganglion cell , neuroprotection , axon , microbiology and biotechnology , pi3k/akt/mtor pathway , gene knockdown , retina , chemistry , gap 43 protein , biology , neuroscience , signal transduction , cell culture , immunology , biochemistry , in vitro , genetics , immunohistochemistry

To investigate, using in vivo and in vitro models, retinal ganglion cell (RGC) neuroprotective and axon regenerative effects and underlying mechanisms of siRTP801, a translatable small-interfering RNA (siRNA) targeting the mTOR negative regulator RTP801.

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