Pgc-1αandNr4a1Are Target Genes of Circadian Melatonin and Dopamine Release in Murine Retina | Zendy

Stefanie Kunst | Zendy; Tanja Wolloscheck | Zendy; Debra K. Kelleher | Zendy; Uwe Wolfrum | Zendy; S. Anna Sargsyan | Zendy; P. Michael Iuvone | Zendy; Kenkichi Baba | Zendy; Gianluca Tosini | Zendy; Rainer Spessert | Zendy

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Pgc-1αandNr4a1Are Target Genes of Circadian Melatonin and Dopamine Release in Murine Retina

Author(s) -

Stefanie Kunst,

Tanja Wolloscheck,

Debra K. Kelleher,

Uwe Wolfrum,

S. Anna Sargsyan,

P. Michael Iuvone,

Kenkichi Baba,

Gianluca Tosini,

Rainer Spessert

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17503

Subject(s) - melatonin , circadian rhythm , receptor , dopamine , biology , dopamine receptor , neurohormones , melatonin receptor , endocrinology , medicine , retina , microbiology and biotechnology , dopamine receptor d2 , neuroscience , genetics , hormone

The neurohormones melatonin and dopamine mediate clock-dependent/circadian regulation of inner retinal neurons and photoreceptor cells and in this way promote their functional adaptation to time of day and their survival. To fulfill this function they act on melatonin receptor type 1 (MT1 receptors) and dopamine D4 receptors (D4 receptors), respectively. The aim of the present study was to screen transcriptional regulators important for retinal physiology and/or pathology (Dbp, Egr-1, Fos, Nr1d1, Nr2e3, Nr4a1, Pgc-1α, Rorβ) for circadian regulation and dependence on melatonin signaling/MT1 receptors or dopamine signaling/D4 receptors.

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