Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model | Zendy

Achim H.P. Krauss | Zendy; Rosa M. Corrales | Zendy; Flavia Pelegrino | Zendy; Johanna Tukler-Henriksson | Zendy; Stephen C. Pflugfelder | Zendy; Cintia S. de Paiva | Zendy

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Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model

Author(s) -

Achim H.P. Krauss,

Rosa M. Corrales,

Flavia Pelegrino,

Johanna Tukler-Henriksson,

Stephen C. Pflugfelder,

Cintia S. de Paiva

Publication year - 2015

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.15-17249

Subject(s) - ccr5 receptor antagonist , integrin , antagonist , fibronectin , flow cytometry , immunology , chemokine , medicine , andrology , pathology , pharmacology , inflammation , cell , chemistry , receptor , chemokine receptor , biochemistry

We investigated the effects of GW559090, a novel, competitive, and high-affinity α4 integrin antagonist, in a murine model of dry eye. Through interaction with vascular cell adhesion molecule 1 (VCAM-1) and fibronectin α4β1 integrin is involved in leukocyte trafficking and activation.

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